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If you’ve spent any time on aesthetic TikTok or in K-beauty forums lately, you’ve probably heard someone breathlessly describe Rejuran as “the salmon DNA thing that fixes everything.” That’s a lot to live up to.

So let’s pull it apart calmly and talk about what Rejuran skin booster actually is, what it does well, what it doesn’t do, and whether it deserves a slot in your skincare plan in Malaysia.

What Rejuran Actually Is (Without the Hype)

Rejuran is an injectable skin booster made from polynucleotides, short strands of purified DNA fragments derived from salmon. When injected into the skin, these polynucleotides act as a kind of biological signal, encouraging your skin cells to repair damage, build collagen, and improve hydration from the inside out. It was developed in South Korea by Pharmaresearch Co., is registered with Malaysia’s Medical Device Authority (MDA), and must be administered by a licensed doctor.

It’s not a filler. It doesn’t add volume. It doesn’t paralyse muscles like Botox does. Think of it less as “putting something into your face” and more as “waking up the repair team that’s already there.” Polynucleotide therapy has been studied in clinical literature for its role in tissue repair, a 2018 review published in the Journal of Cosmetic Dermatology noted polynucleotides’ ability to promote fibroblast proliferation and collagen synthesis in aging skin.

What Rejuran Is Good At

In honest practice, Rejuran tends to shine for:

Dull, dehydrated, tired-looking skin, especially the kind that doesn’t bounce back the way it used to
Fine crepey lines around the eyes, mouth, and on the cheeks
Mild acne scars and uneven texture, particularly soft, rolling scars
Thin skin under the eyes that shows shadows and tired bags
Post-laser or post-acne skin that needs help calming down

Patients in Malaysia tend to like it because our humidity-then-aircon climate is rough on the skin barrier. Rejuran’s repair-focused action genuinely helps with that “my skin just looks stressed” feeling that no amount of moisturiser seems to fix.

**What Rejuran Is Not Going To Do**

This is the part the TikToks usually skip.

It won’t lift sagging skin. For that, you’re looking at HIFU, Ultherapy, thread lifts, or surgery.
It won’t replace volume loss, that’s filler territory.
It won’t erase deep wrinkles or deep ice-pick acne scars in one go.
It won’t work overnight. Most people see meaningful change after the second or third session.

If a clinic tells you Rejuran will do everything, they’re either over-promising or trying to sell you only the treatment they have. A good consultation will be honest about combining treatments such as Rejuran for skin quality, something else for lifting or volume.

The Different Types of Rejuran (Yes, There Are Several)

This trips a lot of patients up, so here’s a quick breakdown:

Type	Best for	Where it’s injected
Rejuran Healer (original)	General skin repair, post-laser recovery	Full face
Rejuran S	Acne scars, uneven texture	Targeted into scarred areas
Rejuran I	Under-eye fine lines, thin skin	Under-eye area
Rejuran HB	Overall hydration and glow	Across the face, blended with HA

A good doctor will choose — or combine — types based on what your skin actually needs, not based on what’s on promotion that month.

What a Rejuran Session Is Actually Like

You arrive, wash your face, and numbing cream goes on for about 20–30 minutes.
The doctor cleans the area and injects Rejuran in tiny doses across the treatment zone, usually with a thin needle, sometimes with a cannula for sensitive areas like under the eyes.
The session itself takes about 15–25 minutes.
You’ll likely see small bumps (often called “blebs”) at the injection sites. These are completely normal and usually settle within a few hours to 1–2 days.
Mild redness, pinpoint bruising, or tenderness can happen. Nothing dramatic.

You can go back to work the same day, though many patients prefer to schedule it before a weekend just so the little bumps can settle without makeup.

How Many Sessions, How Often?

Rejuran works as a course of treatments, not a one-off. A typical protocol is 3 to 4 sessions, spaced 2 to 4 weeks apart, followed by maintenance every 3 to 6 months depending on your goals and age.

You may notice skin feeling more hydrated and “settled” after the first session, but the visible texture and tone improvements usually become obvious after sessions two and three. Patience matters here, this is a regeneration treatment, not a paint job.

Is Rejuran Safe?

Polynucleotides have been used in medicine for years (far beyond aesthetics) and Rejuran has a strong safety record when administered by a qualified doctor. The risks, when they happen, are usually minor: bruising, swelling, tenderness, and the occasional small bump that takes a few extra days to settle.

The bigger safety question isn’t really about the product. It’s about who is injecting it. In Malaysia, all aesthetic injectable procedures must be performed by a doctor credentialed under the Academy of Medicine Malaysia’s LCP framework. Beauty salons offering “Rejuran-like” treatments are a hard no. The needle goes into the dermis, that’s medical territory.

Is Rejuran Worth It?

That depends on what you want. If you’re looking for healthier, more resilient, better-quality skin, the kind that looks rested without filters. Rejuran is one of the more reliable tools in modern aesthetic medicine. If you’re looking for dramatic lifting, plumping, or wrinkle erasure in a single session, Rejuran on its own won’t get you there, and that’s okay. Most patients we see do best with a small, sensible combination plan rather than chasing one miracle treatment.

Rejuran at Beleco Clinic

At Beleco Clinic, we run Rejuran consultations at all our branches in Puchong, Petaling Jaya, Kuala Lumpur, and Klang. Our doctors are LCP-registered, we use authentic, MDA-approved Rejuran products, and we’ll tell you honestly if Rejuran isn’t actually the right starting point for your skin. Sometimes it’s better to begin with a barrier-repair plan, a peel, or a different injectable, and add Rejuran later.

If you’re curious whether Rejuran could fit into your routine, the easiest next step is a real conversation with a doctor who’ll actually look at your skin.

👉 Learn more about Rejuran at Beleco Clinic
👉 Book a consultation — no pressure, no obligation, just clarity on what’s right for you.

Frequently Asked Questions

Is Rejuran the same as Profhilo?

No. Both are injectable skin boosters but they work differently. Profhilo is made from hyaluronic acid and primarily improves hydration and firmness. Rejuran uses polynucleotides and focuses on cellular repair and collagen stimulation. Some patients use both in a combined programme.

Does Rejuran hurt?

With numbing cream, most patients describe it as mildly uncomfortable rather than painful — a light prickling sensation. The under-eye area tends to be more sensitive than the cheeks or forehead.

How soon will I see results?

Most patients notice their skin feels more hydrated and "settled" after the first session. Visible improvements in texture and tone usually appear clearly after the second or third session, around 4–6 weeks in.

Can I wear makeup after Rejuran?

It's best to avoid makeup for 24 hours after treatment to reduce the risk of irritation or infection at the injection sites. Most patients schedule treatments before a weekend for this reason.

Is Rejuran suitable for all skin types and tones?

Yes. Rejuran carries no risk of post-inflammatory hyperpigmentation (PIH), making it safe across all Asian skin tones. It's also suitable for sensitive skin, as polynucleotides are biocompatible and rarely cause allergic reactions.

How is Rejuran different from fillers?

Fillers add volume to specific areas such as the lips, cheeks, and nasolabial folds. Rejuran adds nothing volumetrically — it works at the cellular level to repair and regenerate skin quality. They serve different purposes and are often used together.

Curious whether Rejuran fits your skin?

Our doctors look at your skin honestly and recommend the right starting point — Rejuran or otherwise.

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This article is for informational purposes only and does not constitute medical advice. Results vary between individuals. Consult a qualified medical practitioner before undergoing any aesthetic treatment.

Rejuran Skin Booster, An Honest Guide